J Mark Brown Selected Research

Sterol O-Acyltransferase 2

10/2014	Cholesterol esters (CE) derived from hepatic sterol O-acyltransferase 2 (SOAT2) are associated with more atherosclerosis than CE from intestinal SOAT2.
8/2006	Liver-specific inhibition of acyl-coenzyme a:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/- mice.

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J Mark Brown Research Topics

Disease

17	Atherosclerosis 01/2019 - 10/2003
16	Obesity 01/2021 - 10/2003
16	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 08/2006
14	Inflammation (Inflammations) 01/2022 - 09/2008
12	Insulin Resistance 04/2022 - 10/2003
9	Neoplasms (Cancer) 01/2022 - 10/2003
9	Fibrosis (Cirrhosis) 01/2022 - 04/2016
7	Non-alcoholic Fatty Liver Disease 04/2022 - 05/2010
7	Hepatocellular Carcinoma (Hepatoma) 01/2022 - 03/2006
6	Metabolic Syndrome (Dysmetabolic Syndrome X) 07/2021 - 09/2008
5	Type 2 Diabetes Mellitus (MODY) 01/2021 - 03/2016
5	Metabolic Diseases (Metabolic Disease) 10/2020 - 04/2013
4	Body Weight (Weight, Body) 01/2019 - 05/2009
3	Liver Diseases (Liver Disease) 01/2022 - 07/2020
3	Fatty Liver 07/2021 - 12/2015
3	Hyperlipidemias (Hyperlipidemia) 01/2020 - 09/2008
3	Thrombosis (Thrombus) 01/2019 - 03/2016
3	Weight Gain 01/2019 - 11/2010
3	Chanarin-Dorfman Syndrome 01/2013 - 10/2007
3	Hypercholesterolemia 06/2012 - 08/2006
2	Glioblastoma (Glioblastoma Multiforme) 07/2021 - 07/2014
2	Renal Cell Carcinoma (Grawitz Tumor) 01/2021 - 01/2020
2	Hepatitis 10/2019 - 01/2017
2	Demyelinating Diseases (Demyelinating Disease) 11/2018 - 10/2018
2	Disease Progression 10/2018 - 01/2018
2	Myocardial Infarction 03/2016 - 05/2013
2	Stroke (Strokes) 03/2016 - 05/2013
2	Hypersensitivity (Allergy) 10/2009 - 09/2008
1	Synucleinopathies 01/2022
1	Multiple System Atrophy 01/2022
1	Premature Aging 01/2022
1	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2022
1	Lung Neoplasms (Lung Cancer) 01/2022
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2021
1	Diabetes Mellitus 01/2021
1	Weight Loss (Weight Reduction) 01/2021
1	Frailty 01/2021

Drug/Important Bio-Agent (IBA)

16	LipidsIBA 07/2021 - 08/2008
15	trimethyloxamine (trimethylamine N-oxide)IBA 01/2022 - 05/2013
12	CholesterolIBA 01/2019 - 03/2006
9	EnzymesIBA 01/2022 - 04/2013
9	Antisense OligonucleotidesIBA 01/2019 - 08/2006
8	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 11/2010
7	dimethylaniline monooxygenase (N-oxide forming) (flavin-containing monooxygenase)IBA 04/2022 - 01/2015
6	Pharmaceutical PreparationsIBA 01/2022 - 06/2010
5	Fatty Acids (Saturated Fatty Acids)IBA 01/2022 - 09/2008
5	Biomarkers (Surrogate Marker)IBA 01/2022 - 07/2014
5	LDL Receptors (LDL Receptor)IBA 01/2019 - 08/2006
5	HydrolasesIBA 11/2018 - 10/2013
4	AcyltransferasesIBA 01/2022 - 08/2006
4	Bile Acids and Salts (Bile Acids)IBA 01/2021 - 01/2017
4	Insulin (Novolin)FDA Link 01/2021 - 02/2012
4	Triglycerides (Triacylglycerol)IBA 01/2015 - 10/2007
3	Hormones (Hormone)IBA 04/2022 - 01/2015
3	Volatile Fatty AcidsIBA 01/2022 - 01/2018
3	trimethylamineIBA 01/2019 - 05/2013
3	DiglyceridesIBA 01/2016 - 11/2010
3	LDL CholesterolIBA 01/2014 - 03/2009
3	Conjugated Linoleic AcidsIBA 04/2013 - 10/2003
3	Lipoproteins (Lipoprotein)IBA 09/2008 - 08/2006
2	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2021
2	Succinic Acid (Succinate)IBA 01/2022 - 01/2022
2	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2022 - 01/2020
2	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 07/2021 - 01/2021
2	HDL LipoproteinsIBA 12/2020 - 07/2015
2	Scavenger Receptors (Scavenger Receptor)IBA 12/2020 - 07/2014
2	CytokinesIBA 10/2020 - 11/2005
2	Phosphotransferases (Kinase)IBA 10/2020 - 11/2017
2	Choline (Choline Chloride)IBA 01/2019 - 03/2016
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2019 - 01/2017
2	EndocannabinoidsIBA 11/2018 - 12/2015
2	Proteins (Proteins, Gene)FDA Link 11/2017 - 04/2013
2	Carnitine (L-Carnitine)FDA LinkGeneric 04/2016 - 05/2013
2	Lipase (Acid Lipase)FDA Link 12/2014 - 08/2014
2	Sterol O-Acyltransferase 2IBA 10/2014 - 08/2006
2	Dietary CholesterolIBA 06/2012 - 05/2010
2	stearoyl-coenzyme A (stearoyl-CoA)IBA 06/2010 - 09/2008
2	Apolipoprotein B-100 (Apo B 100)IBA 05/2010 - 09/2008
2	Stearoyl-CoA DesaturaseIBA 01/2010 - 10/2009
2	Toll-Like Receptor 4IBA 10/2009 - 09/2008
2	Sterol O-AcyltransferaseIBA 04/2008 - 08/2006
1	Environmental Pollutants (Pollutants, Environmental)IBA 04/2022
1	DioxinsIBA 04/2022
1	lipopolysaccharide-binding proteinIBA 01/2022
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2022
1	Butyric Acid (Butanoic Acid)IBA 01/2022
1	Inosine Triphosphate (ITP)IBA 01/2022
1	HMGB1 Protein (HMG1)IBA 01/2022
1	MicroRNAs (MicroRNA)IBA 01/2022
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2022
1	LipopolysaccharidesIBA 01/2022
1	alpha-Fetoproteins (alpha-Fetoprotein)IBA 01/2022
1	P-2 (P 2)IBA 08/2021
1	Hypoglycemic Agents (Hypoglycemics)IBA 07/2021
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 07/2021
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2021

Therapy/Procedure

11	Therapeutics 01/2022 - 01/2010
1	Aftercare (After-Treatment) 01/2022
1	Drug Therapy (Chemotherapy) 07/2021
1	Chemoprevention 07/2021